Synthesis of Azulen-1-yl Ketones via Oxidative Cleavage
of C–C Multiple Bonds in <i>N</i>‑Sulfonyl
Enamides and 1‑Alkynes under Air and Natural Sunlight
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Abstract
A synthetic method
to prepare azulen-1-yl ketones was developed
via oxidative cleavage of the C–C double bond in the reaction
of easily obtainable <i>N</i>-sulfonyl enamides with Cs<sub>2</sub>CO<sub>3</sub> under air and natural sunlight and in the absence
of a photosensitizer. Oxidative cleavage of C–C triple bonds
was also demonstrated for the synthesis of azulen-1-yl ketones via
a tandem Cu-catalyzed [3 + 2] cycloaddition, Rh-catalyzed arylation,
photooxygenation, and ring-opening reaction in one pot under air and
natural sunlight