Construction of 1‑Naphthols via Benzannulation Based on the Reaction of Aryl <i>tert</i>-Butyl Ynol Ethers with Ynamides or Ynol Ethers
- Publication date
- Publisher
Abstract
A new
version of benzannulation featuring the use of aromatic <i>tert</i>-butyl ynol ethers as the convenient precursors for
arylketenes has been developed. Both ynamides and ynol ethers undergo
this reaction smoothly, giving 3-amino and 3-alkoxy 1-naphthols in
good to excellent yields under the heated reaction conditions. The
high efficiency, excellent regioselectivity, good functional group
compatibility, and broad substrate scope render this reaction particularly
valuable for organic synthesis