<p>At E17.5 both control and bigenic tubular epithelial cells express Sox9. Sox9 (green <b>AB</b>); DBA (green, <b>CD</b>); GLUT2 (green, <b>EF</b>); Insulin (red); DAPI (blue). The boxed areas in E and F are enlarged (<b>GH</b>: merged channels, <b>IJ</b>: green channel showing GLUT2 expression). Higher GLUT2 staining intensity is seen in the bigenic tubular epithelial cells than in the controls. In bigenic pancreas GLUT2 staining intensity is comparable in insulin<sup>+</sup> (marked by arrows) and insulin<sup>-</sup> tubular epithelial cells (marked by arrowheads) whereas in control pancreas GLUT2 staining intensity is reduced in tubular epithelial cells than islets. Bar: 20 μm.</p
