MetAnnotate estimates microbial community abundance with high accuracy, demonstrated by estimated class-level taxonomic composition of the Simulated High Complexity Metagenome (simHC) dataset based on the taxonomic markers in Fig. 3a. The community abundance prediction made by MG-RAST (default parameters, LCA option) and three other methods are included for comparison. The Spearman correlations between known and estimated taxonomic abundance are: r = 0.82 (MetAnnotate); r = 0.75 (MG-RAST); r = 0.70 (MiniKraken); r = 0.65 (FCP NB-BL); r = 0.68 (FCP Epsilon-NB). (PDF 44 kb
