One-Pot Synthesis of Pyrrolo­[3,2,1-<i>kl</i>]pheno­thiazines through Copper-Catalyzed Tandem Coupling/Double Cyclization Reaction

Abstract

A novel and efficient synthesis of pyrrolo­[3,2,1-<i>kl</i>]­pheno­thiazines has been developed through a Cu­(I)-catalyzed tandem C–S coupling/double cyclization process. Using 2-alkynyl-6-iodoanilines and <i>o</i>-bromo­benzenethiols as the starting materials, a wide range of pyrrolo­[3,2,1-<i>kl</i>]­pheno­thiazine derivatives were facilely and efficiently generated in one pot under Cu­(I) catalysis