Ni(II)-Catalyzed Highly Stereo- and Regioselective
Syntheses of Isoindolinones and Isoquinolinones from <i>in Situ</i> Prepared Aldimines Triggered by Homoallylation/Lactamization Cascade
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Abstract
An efficient route to isoindolinones
and isoquinolinones has been
achieved via a domino Ni-catalyzed homoallylation/lactamization from <i>in situ</i> prepared imines, derived from <i>o</i>-formyl benzoates and <i>o</i>-formyl arylacetates, with
conjugated dienes promoted by diethylzinc. The reaction proceeds smoothly
at room temperature for a variety of aldehydes, amines, and dienes.
The method involves one C–C and two C–N bond forming
events under operationally simple conditions