SilverCatalyzed Cascade Carboxylation and Cyclization
of Trimethyl(2-methylenebut-3-yn-1-yl)silane Derivatives
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Abstract
C–C bond-forming carboxylation
and cyclization of trimethyl(2-methylenebut-3-yn-1-yl)silane
derivatives and carbon dioxide was developed. Silver catalysts and
CsF promoted the reaction to afford the corresponding 2-furanone and
2-pyrone derivatives in good-to-high yields. The structure of the
2-furanone was confirmed by single-crystal X-ray crystallography,
which revealed that the geometry of the <i>exo</i>-olefin
was that of a <i>Z</i>-isomer. When an aromatic ring-substituted
alkyne was used, 2-furanone derivatives were selectively obtained
via 5-<i>exo-dig</i> cyclization, whereas the reaction of
alkyl-substituted alkynes produced 2-pyrone derivatives with high
selectivity