12,17-Cyclojatrophane and Jatrophane Constituents
of <i>Euphorbia welwitschii</i>
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Abstract
Euphowelwitschines A (<b>1</b>) and B (<b>2</b>), isolated
from a methanolic extract of <i>Euphorbia welwitschii</i>, exhibit a rare combination of structural features in having a 5/8/8
fused-ring system and a 12,15-ether bridge. Moreover, the isolation
of the additional new compounds welwitschene (<b>3</b>) and
epoxywelwitschene (<b>4</b>) has provided insights into the
biogenetic pathway of 12,17-cyclojatrophanes. The structures of <b>1</b>–<b>4</b> were determined by spectroscopic methods
inclusive of 1D and 2D NMR experiments and X-ray crystallography for
compounds <b>1</b> and <b>2</b>. Preliminary information
on the selective antiproliferative activity of compounds <b>1</b>–<b>4</b> is also described
