Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated <i>Streptomyces</i> sp.

Abstract

A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, <i>Streptomyces</i> sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam’s structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant <i>Candida albicans</i> (MIC = 4 μg/mL, 8.3 μM)