Boronate-Mediated Biologic
Delivery
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Abstract
Inefficient cellular delivery limits the landscape of
macromolecular
drugs. Boronic acids readily form boronate esters with the 1,2- and
1,3-diols of saccharides, such as those that coat the surface of mammalian
cells. Here pendant boronic acids are shown to enhance the cytosolic
delivery of a protein toxin. Thus, boronates are a noncationic carrier
that can deliver a polar macromolecule into mammalian cells