Discovery of Natural Phenols
as G Protein-Coupled
Receptor-35 (GPR35) Agonists
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Abstract
We report the discovery and characterization of natural
phenols
as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological
characterization using label-free dynamic mass redistribution and
Tango β-arrestin translocation assays revealed that GPR35-active
natural phenols are divergent in their biased agonism