Efficient Carbazole Synthesis via Pd/Cu-Cocatalyzed
Cross-Coupling/Isomerization of 2‑Allyl-3-iodoindoles and Terminal
Alkynes
- Publication date
- Publisher
Abstract
The Pd/Cu-cocatalyzed one-pot reaction
of 2-allyl-3-iodo-1-tosyl-1<i>H</i>-indoles and terminal
alkynes afforded carbazoles highly
efficiently via sequential carbon–carbon coupling, isomerization,
cyclization, and aromatization forming a benzene ring. Both Pd and
Cu are responsible for the coupling step, while K<sub>2</sub>CO<sub>3</sub> was observed to be critical for the subsequent cyclization