Use of 2‑Bromophenylboronic Esters as Benzyne
Precursors in the Pd-Catalyzed Synthesis of Triphenylenes
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Abstract
<i>ortho</i>-Substituted
aryl boronates are introduced
as aryne precursors for transition-metal-catalyzed transformations.
On treatment with <sup><i>t</i></sup>BuOK and Pd(0), metal-bound
aryne intermediates are formed that undergo effective trimerization
to form useful triphenylene compounds. For <i>meta</i>-substituted
arynes, the 3:1 product ratio in favor of non-C<sub>3</sub> symmetric
material is indicative of a benzyne mechanism