Effects
of Graphene Nanopore Geometry on DNA Sequencing
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Abstract
In
this Letter we assess the effect of graphene nanopore geometries
on DNA sequencing by considering DNA fragments including A, T, C,
G, and 5-methylcytosine (MC) pulled out of graphene nanopores of different
geometries with diameters down to ∼1 nm. Using steered molecular
dynamics simulations it is demonstrated that the bases (A, T, C, G,
and MC) can be indentified at single-base resolution through the characteristic
peaks on the force profile in a circular graphene nanopore but not
in nanopores with other asymmetric geometries. Our study suggests
that the graphene nanopore surface should be modified as symmetrically
as possible in order to sequence DNA by atomic force microscopy or
optical tweezers