Changes in the Morphology and Proliferation of Astrocytes
Induced by Two Modalities of Chemically Functionalized Single-Walled
Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic
Protein
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Abstract
Alterations in glial fibrillary acidic
protein (GFAP) levels accompany
the changes in the morphology and proliferation of astrocytes induced
by colloidal solutes and films of carbon nanotubes (CNTs). To determine
if GFAP is required for the effects of CNTs on astrocytes, we used
astrocytes isolated from GFAP null mice. We find that selected astrocytic
changes induced by CNTs are mediated by GFAP, i.e., perimeter, shape,
and cell death for solutes, and proliferation for films