Two-Photon
Neuronal and Astrocytic Stimulation with
Azobenzene-Based Photoswitches
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Abstract
Synthetic photochromic compounds
can be designed to control a variety
of proteins and their biochemical functions in living cells, but the
high spatiotemporal precision and tissue penetration of two-photon
stimulation have never been investigated in these molecules. Here
we demonstrate two-photon excitation of azobenzene-based protein switches
and versatile strategies to enhance their photochemical responses.
This enables new applications to control the activation of neurons
and astrocytes with cellular and subcellular resolution