Denhaminols
A–H, Dihydro-β-agarofurans
from the Endemic Australian Rainforest Plant <i>Denhamia celastroides</i>
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Abstract
Eight new dihydro-β-agarofurans,
denhaminols A–H (<b>1</b>–<b>8</b>), were
isolated from the leaves of
the Australian rainforest tree <i>Denhamia celastroides</i>. The chemical structures of <b>1</b>–<b>8</b> were elucidated following analysis of 1D/2D NMR and MS data. The
absolute configuration of denhaminol A (<b>1</b>) was determined
by single-crystal X-ray crystallography. All compounds were evaluated
for cytotoxic activity against the human prostate cancer cell line
LNCaP, using live-cell imaging and metabolic assays. Denhaminols A
(<b>1</b>) and G (<b>7</b>) were also tested for their
effects on the lipid content of LNCaP cells. This is the first report
of secondary metabolites from <i>D. celastroides.</i
