Ligand-Promoted Alkylation of C(sp³)–H and C(sp²)–H Bonds

Abstract

9-Methylacridine was identified as a generally effective ligand to promote a Pd­(II)-catalyzed C­(sp³)–H and C­(sp²)–H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids