Flow of the detection process: (a) H&E image, (b) CD20 image, (c) S channel of H&E, (d) S channel of CD20, (e) Registered CD20 (S channel), (f) Local thresholding with blocks showing detected HPF regions, (g) Detected HPFs on CD20 (S channel), (h) Detected HPFs on the H&E. (DOCX 384 kb