Regioselective Carbonylation of <i>trans</i>-Disubstituted Epoxides to β‑Lactones: A Viable Entry into <i>syn</i>-Aldol-Type Products
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Abstract
Two
new catalysts are reported for the regioselective carbonylation
of <i>trans</i>-disubstituted epoxides to <i>cis</i>-β-lactones. The two catalysts display high and opposing selectivities,
which generally are difficult to achieve for this class of epoxides.
The resulting β-lactones are well-defined precursors for a wide
variety of aldol-type compounds. Altogether, carbonylation of disubstituted
epoxides is established as a viable and economical entry into <i>syn</i>- and <i>anti</i>-aldol products