Additional file 1: Figure S1. of Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1
IPS-1 −/− mice have lower IFN-α levels in serum after LGTV infection compared to WT mice. WT and IPS-1 −/− mice were infected intraperitoneally with 104 FFU of LGTV, and serum samples were collected at indicated time points (n = 5–10). The amount of IFN-α in the mouse serum was determined by enzyme linked immunosorbent assay (ELISA) according to the manufacturer’s instructions (PBL). Significance was calculated with student’s T test, *p < 0.05. (PDF 53.6 KB
