<p>The most sensitive parameter was (P) the tubular dilation score, which increased already after 10-min ischemia (C, H and M) compared to control-operated (ctrl-op; B, G and L) (* p<0.05 vs. non-operated (non-op) and p<0.001 vs. control-operated (ctrl-op); ** p<0.001 vs. non-op and ctrl-op). (Q) Tubular necrosis and (R) casts were present mostly after 20- (D, I and N) and 30-min (E, J and O) ischemia († p<0.05 vs. non-op, p<0.01 vs. ctrl-op, 10- and 30-min ishemia; ‡ p<0.0001 non-op, ctrl-op and 10-min ischemia, p<0.01 vs. 20-min ischemia; ¶ p<0.05 vs. non-op, p<0.01 vs. ctrl-op and 10-min ischemia, p<0.0001 vs. 30-min ischemia; *¶ p<0.0001 vs. non-op, ctrl-op, 10- and 20-min ischemia). There was no significant histologic change between non-op (A, F and K) and ctrl-op. (S) Renal function measured by blood urea nitrogen retention worsened after 20-min ischemia (# p<0.0001 vs. non-op, ctrl-op (ctrl-op) and 10-min ischemia). (non-op: n = 4; ctrl-op: n = 6; 10-min: n = 7; 20 min: n = 7; 30 min: n = 16).</p
