H-bonding network in the active site of the TBBL-bound rh-PON1 protein complexes.

Abstract

<p>The amino acid residues of the rh-PON1 proteins are shown in stick format and colour by atom type (<b>red</b>–oxygen; <b>blue</b>–nitrogen). The yellow broken lines show H-bonding interaction between the amino acid residues. Catalytic calcium is represented by yellow spheres. <b>Panels (A-D)</b> depict rh-PON1_(wt), rh-PON1_(H115W,R192), rh-PON1_{(H115W,R192K)}, and rh-PON1_{(H115W,R192I)} proteins. Differential H-bonding network around position 192 was observed in these proteins.</p