Behavioral characterization of the separated C57BL/6NxC3B <i>Del/+</i> and <i>Dup/+</i> cohorts.

Abstract

<p>(A) Circadian activity test. Graphs plot the ambulatory activity (count) and the vertical activity/rears (count) during dark and light phases. (B) Open field test. Distance travelled (m), vertical activity/rears (count) and time percentage spent in the central area over 30 min of testing. (C) Repetitive behavior data. Observations of rearing, jumping, climbing and digging behaviors during 10 min of observation in a novel cage. (D) Social interaction test. Graph plots the duration of sniffing and following behaviors. (E) Novel object recognition test. Discrimination index was calculated as the ratio of time spent exploring the novel object vs the familiar object in the choice trial. (F) Motor coordination evaluation. Graphs plot the latency (s) that mice stayed on the rod before falling under acceleration speed over 3 consecutive days of test. Data are represented as the mean + SEM. *<i>P</i> < 0.05, **<i>P</i> < 0.01 and ***<i>P</i> < 0.001, significantly different from matched wt littermates, Student’s t-test.</p