Inhibition of thrombin generation in zebrafish by inhibition of platelet aggregation.

Abstract

<p>Zebrafish were treated with 30 μg/g aspirin or vehicle for 30 min <b>(A-B)</b> or were allowed to swim in aspirin-supplemented water (250 mg/ml) for 24 hours <b>(C-D)</b>, followed by thrombin generation measurements. <b>(A,C)</b> Thrombin generation curves are shown. <b>(B,D)</b> Results are expressed as the percentage inhibition compared to a control group of vehicle-treated fish (n = 5). The percentage CV is indicated for all parameters. *Mann-Whitney U-test as compared to controls.</p