Effect of the E1E2p7 mutations on sensitivity to inhibition by GNA, CV-N, ConA and GRFT.

Abstract

<p>Inhibition assays were performed by incubating WT or mutant HCVcc with various concentrations of GNA (<b>A</b>), CV-N (<b>B</b>), ConA (<b>C</b>) or GRFT (<b>D</b>). After a 1 h incubation at 37°C, mixes were put into contact with target cells for 4 h. Luciferase assays were performed on infected cells at 72 h post-infection. Results are expressed as percentages of infectivity compared to infection in absence of inhibitory protein and are reported as the means ± S.D. of at least three independent experiments.</p