Palladacycle-Catalyzed Deacetonative
Sonogashira Coupling
of Aryl Propargyl Alcohols with Aryl Chlorides
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Abstract
An efficient and
general protocol for the deacetonative Sonogashira
coupling of aryl propargyl alcohols with aryl chlorides is described.
The reaction proceeded smoothly with the catalyst system of palladacycle/Xphos.
This result represents the first successful deacetonative Sonogashira
version for electron-poor, electron-neutral, and even inactive sterically
hindered electron-rich aryl chlorides