γ‑Carbonyl Quinones: Radical Strategy for the Synthesis of Evelynin and Its Analogues by C–H Activation of Quinones Using Cyclopropanols
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Abstract
Cyclopropanols, on oxidative ring opening with AgNO<sub>3</sub>–K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> in DCM–H<sub>2</sub>O at room temperature and under open flask conditions, produced β-keto radicals which were successfully added to quinones to furnish γ-carbonyl quinones. This mild method has been applied to the synthesis of cytotoxic natural products, 4,6-dimethoxy-2,5-quinodihydrochalcone and evelynin