Identification of a Series of Compounds with Potent
Antiviral Activity for the Treatment of Enterovirus Infections
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Abstract
Rhinovirus
(genus enterovirus) infections are responsible for many
of the severe exacerbations of asthma and chronic obstructive pulmonary
disease. Other members of the genus can cause life-threatening acute
neurological infections. There is currently no antiviral drug approved
for the treatment of such infections. We have identified a series
of potent, broad-spectrum antiviral compounds that inhibit the replication
of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71.
The mechanism of action of the compounds has been established as inhibition
of a lipid kinase, PI4KIIIβ. Inhibition of hepatitis C replication
in a replicon assay correlated with enterovirus inhibition
