Ultrasensitive
Fiber Enhanced UV Resonance Raman Sensing
of Drugs
- Publication date
- Publisher
Abstract
Fiber
enhanced UV resonance Raman spectroscopy is introduced for
chemical selective and ultrasensitive analysis of drugs in aqueous
media. The application of hollow-core optical fibers provides a miniaturized
sample container for analyte flow and efficient light-guiding, thus
leading to strong light–analyte interactions and highly improved
analytical sensitivity with the lowest sample demand. The Raman signals
of the important antimalaria drugs chloroquine and mefloquine were
strongly enhanced utilizing deep UV and electronic resonant excitation
augmented by fiber enhancement. An experimental design was developed
and realized for reproducible and quantitative Raman fiber sensing,
thus the enhanced Raman signals of the pharmaceuticals show excellent
linear relationship with sample concentration. A thorough model accounts
for the different effects on signal performance in resonance Raman
fiber sensing, and conclusions are drawn how to improve fiber enhanced
Raman spectroscopy (FERS) for chemical selective analysis with picomolar
sensitivity