Leukocyte-Mimicking Stem Cell Delivery via in Situ
Coating of Cells with a Bioactive Hyperbranched Polyglycerol
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Abstract
Since stem cells
emerged as a new generation of medicine, there
are increasing efforts to deliver stem cells to a target tissue via
intravascular injection. However, the therapeutic stem cells lack
the capacity to detect and adhere to the target tissue. Therefore,
this study presents synthesis of a bioactive hyperbranched polyglycerol
(HPG) that can noninvasively associate with stem cells and further
guide them to target sites, such as inflamed endothelium. The overall
process is analogous to the way in which leukocytes are mobilized
to the injured endothelium