Cu(OTf)<sub>2</sub>‑Catalyzed Asymmetric Friedel–Crafts
Alkylation Reaction of Indoles with Arylidene Malonates Using Bis(sulfonamide)-Diamine
Ligands
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Abstract
A highly efficient Cu-catalyzed asymmetric
Friedel–Crafts
alkylation reaction of indoles with arylidene malonates using simple,
stable, and easily prepared bis-sulfonamide diamine ligands was developed.
The desired products were obtained in up to 99% yield with 96% ee