Microfluidic Synthesis of Cell-Type-Specific Artificial
Extracellular Matrix Hydrogels
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Abstract
Droplet
microfluidic technology is applied for the high-throughput
synthesis via Michael-type addition of reactive, micrometer-sized
poly(ethylene glycol) (PEG) hydrogels (“microgels”)
with precisely controlled dimension and physicochemical properties.
A versatile chemical scheme is used to modify the reactive PEG microgels
with tethered biomolecules to tune their bioactive properties for
the bioreactor culture and manipulation of various (stem) cell types