Diastereo- and Enantioselective Asymmetric Hydrogenation of α‑Amido-β-keto Phosphonates via Dynamic Kinetic Resolution
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Abstract
Dynamic kinetic resolution of various α-amido-β-keto phosphonates via asymmetric hydrogenation proceeded efficiently to give the corresponding β-hydroxy-α-amido phosphonates in high diastereo- and enantioselectivities (up to 99:1 syn/anti, 99.8% ee). The addition of catalytic amounts of CeCl<sub>3</sub>·7H<sub>2</sub>O is necessary to achieve both good selectivity and catalytic efficiency under mild reaction conditions
