Cellular Interactions
with Photo-Cross-Linked and
pH-Sensitive Polymersomes: Biocompatibility and Uptake Studies
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Abstract
Polymeric nanoparticles, specifically polymersomes, are
at the
leading edge of the rapidly developing field of nanotechnology. However,
their use for biological applications is primarily limited by the
biocompatibility of the components. Hence, optimization of polymersome
synthesis protocols should carefully consider aspects of cellular
toxicity. In this work, we investigate the viability of HDF and HeLa
cells treated with photo-cross-linked and pH-sensitive polymersomes.
We demonstrate how aspects of polymersome preparation conditions such
as cross-linking density and UV irradiation time may affect their
cytotoxic properties. Additionally, we also study the cellular uptake
of our polymersomes into the cell types mentioned