Indium-Catalyzed Reductive Bromination of Carboxylic Acids Leading to Alkyl Bromides

Abstract

The combination of 1,1,3,3-tetramethyldisiloxane (TMDS) and trimethylbromosilane (Me₃SiBr) with a catalytic amount of indium bromide (InBr₃) undertook direct bromination of carboxylic acids, which produced the corresponding alkyl bromides in good to excellent yields. The reducing system was tolerant to several functional groups