Amidine-Mediated Zwitterionic Polymerization of Lactide

Abstract

The ring-opening polymerization (ROP) of lactide with DBU (1,8-diazabicyclo[5.4.0] undec-7-ene) is described. Room temperature polymerization using the neutral amine catalyst DBU in the absence of any other initiator produces polymers with narrow polydispersities and shows a linear relationship between molecular weight and conversion. The resulting polymers were characterized and determined to be cyclic. DFT calculations support a mechanistic hypothesis involving a zwitterionic acyl amidinium intermediate