Iron-Catalyzed Formation of 2‑Aminopyridines from Diynes and Cyanamides
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Abstract
Diynes and cyanamides undergo an iron-catalyzed [2 +
2 + 2] cycloaddition to form highly substituted 2-aminopyridines in
an atom-efficient manner that is both high yielding and regioselective.
This system was also used to cyclize two terminal alkynes and a cyanamide
to afford a 2,4,6-trisubstituted pyridine product regioselectively
