Point Group Symmetry Determination
via Observables
Revealed by Polarized Second-Harmonic Generation Microscopy: (2) Applications
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Abstract
In this work, the theory presented in part 1 (van der
Veen, M.
A.; Vermoortele, F.; De Vos, D. E.; Verbiest, T. <i>Anal. Chem.</i> <b>2012</b>, DOI: 10.1021/ac300936q) for determination of
the point groups symmetry based on easily distinguishable observables
present in simple polarization dependent tests in second harmonic
generation microscopy is tested. It is shown experimentally that the
methodology can be applied for point group symmetry determination
for a variety of structures among which molecular crystals and host/guest
systems where the symmetry of the guest molecules cannot be inferred
from conventional diffraction methods. Uniquely, this second-harmonic
generation based method can discriminate between chiral and achiral
structures regardless of their orientation. The method allows for
in situ and in vivo studies with spatial resolution