Racemization of a Chiral
Nanoparticle Evidences the
Flexibility of the Gold–Thiolate Interface
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Abstract
Thiolate-protected gold nanoparticles and clusters combine
size-dependent
physical properties with the ability to introduce (bio)chemical functionality
within their ligand shell. The engineering of the latter with molecular
precision is an important prerequisite for future applications. A
key question in this respect concerns the flexibility of the gold–sulfur
interface. Here we report the first study on racemization of an intrinsically
chiral gold nanocluster, Au<sub>38</sub>(SCH<sub>2</sub>CH<sub>2</sub>Ph)<sub>24</sub>, which goes along with a drastic rearrangement of
its surface involving place exchange of several thiolates. This racemization
takes place at modest temperatures (40–80 °C) without
significant decomposition. The experimentally determined activation
energy for the inversion reaction is ca. 28 kcal/mol, which is surprisingly
low considering the large rearrangement. The activation parameters
furthermore indicate that the process occurs without complete Au–S
bond breaking