Crystallization Control
and Physicochemical Properties
of Polymorphic Forms of the Factor Xa Inhibitor KFA-1982
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Abstract
Many polymorphs of KFA-1982, an orally active factor
Xa (fXa) inhibitor,
have been identified and their physicochemical properties have been
investigated. Form B was selected as the oral API form because of
its superior stability and solubility characteristics. Crystallization
conditions for form B were thoroughly investigated including the role
of water in hydrate formation and the use of antisolvents and supersaturation
in polymorph control
