Biosynthetically Intriguing
Chlorinated Lipophilic
Metabolites from Geographically Distant Tropical Marine Cyanobacteria
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Abstract
Five new vinylchlorine-containing metabolites, the lipoamides
janthielamide
A and kimbeamides A–C and the ketide-extended pyranone kimbelactone
A, have been isolated from collections of marine cyanobacteria made
in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide
A exhibited moderate sodium channel blocking activity in murine Neuro-2a
cells. Consistent with this activity, janthielamide A was also found
to antagonize veratridine-induced sodium influx in murine cerebrocortical
neurons. These lipoamides represent the newest additions to a relatively
rare family of marine cyanobacterial-derived lipoamides and a new
structural class of compounds exhibiting neuromodulatory activities
from marine cyanobacteria