Efficient Synthesis of
Impurity-C of Antimigraine
Agent Rizatriptan Benzoate
- Publication date
- Publisher
Abstract
During the commercial manufacturing of antimigraine drug
Rizatriptan
benzoate, several impurities are reported to be formed. This present
work demonstrates a convergent and short synthesis of the most critical
impurity (C) of Rizatriptan, [2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indole-2-yl)-<i>N</i>,<i>N</i>-dimethylethanamine (<b>1</b>)],
recently reported in U.S. Pharmacopeia