Iron(III)/NaBH<sub>4</sub>-Mediated Additions to Unactivated Alkenes: Synthesis of Novel 20′-Vinblastine Analogues
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Abstract
An Fe(III)/NaBH<sub>4</sub>-mediated reaction for the functionalization of unactivated alkenes is described defining the alkene substrate scope, establishing the exclusive Markovnikov addition, exploring a range of free radical traps, examining the Fe(III) salt and initiating hydride source, introducing H<sub>2</sub>O–cosolvent mixtures, and exploring catalytic variants. Its use led to the preparation of a novel, potent, and previously inaccessible C20′-vinblastine analogue
