Core/Shell Nanofibers
with Embedded Liposomes as a
Drug Delivery System
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Abstract
The broader application of liposomes in regenerative
medicine is
hampered by their short half-life and inefficient retention at the
site of application. These disadvantages could be significantly reduced
by their combination with nanofibers. We produced 2 different nanofiber-liposome
systems in the present study, that is, liposomes blended within nanofibers
and core/shell nanofibers with embedded liposomes. Herein, we demonstrate
that blend electrospinning does not conserve intact liposomes. In
contrast, coaxial electrospinning enables the incorporation of liposomes
into nanofibers. We report polyvinyl alcohol-core/poly-ε-caprolactone-shell
nanofibers with embedded liposomes and show that they preserve the
enzymatic activity of encapsulated horseradish peroxidase. The potential
of this system was also demonstrated by the enhancement of mesenchymal
stem cell proliferation. In conclusion, intact liposomes incorporated
into nanofibers by coaxial electrospinning are very promising as a
drug delivery system