Cytotoxic Phloroglucinols from the Leaves of <i>Myrtus communis</i>

Abstract

Bioactivity-guided fractionation of a dichloromethane extract of the leaves of <i>Myrtus communis</i> led to the isolation of phloroglucinol derivatives. The structures of the new myrtucommulones J, K, and L (<b>1</b>–<b>3</b>) and the previously known myrtucommulone A (<b>4</b>) were elucidated on the basis of extensive 1D and 2D NMR experiments as well as high-resolution mass spectrometry. Myrtucommulone J was obtained as a tautomeric pair (<b>1</b>/<b>1a</b>). The compounds were tested in vitro for their cytotoxic and antibacterial activities