Cytotoxic Phloroglucinols
from the Leaves of <i>Myrtus communis</i>
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Abstract
Bioactivity-guided fractionation of a dichloromethane
extract of the leaves of <i>Myrtus communis</i> led to the
isolation of phloroglucinol derivatives. The structures of the new
myrtucommulones J, K, and L (<b>1</b>–<b>3</b>)
and the previously known myrtucommulone A (<b>4</b>) were elucidated
on the basis of extensive 1D and 2D NMR experiments as well as high-resolution
mass spectrometry. Myrtucommulone J was obtained as a tautomeric pair
(<b>1</b>/<b>1a</b>). The compounds were tested in vitro
for their cytotoxic and antibacterial activities