Multicatalytic Asymmetric Synthesis of Complex Tetrahydrocarbazoles via a Diels–Alder/Benzoin Reaction Sequence
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Abstract
Expanding upon the recently developed aminocatalytic asymmetric indole-2,3-quinodimethane strategy, a straightforward synthesis of structurally and stereochemically complex tetrahydrocarbazoles has been devised. The chemistry’s complexity-generating power was further harnessed by designing a multicatalytic, one-pot Diels–Alder/benzoin reaction sequence to stereoselectively access <i>trans</i>-fused tetracyclic indole-based compounds having four stereogenic centers with very high fidelity