Self-Assembly of a Confined
Rhodium Catalyst for Asymmetric
Hydroformylation of Unfunctionalized Internal Alkenes
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Abstract
A chiral supramolecular ligand has been assembled and
applied to
the rhodium-catalyzed asymmetric hydroformylation of unfunctionalized
internal alkenes. Spatial confinement of the metal center within a
chiral pocket results in reversed regioselectivity and remarkable
enantioselectivities