Molecular Thioamide ↔
Iminothiolate Switches
for Sulfur Mustards
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Abstract
SNS platinum(II) pincer complexes reversibly bind and
release the
surrogate half sulfur mustard, 2-chloroethyl ethyl sulfide (CEES).
The switch-like behavior of the pincers is attributed to a reversible
transformation between the thioamide and iminothiolate forms of the
pincer skeleton under slightly acidic and basic conditions, respectively.
An amide-based palladium(II) pincer complex also binds CEES, as confirmed
crystallographically and by NMR