Palladium-Catalyzed Intramolecular
C–H Activation/C–C
Bond Formation: A Straightforward Synthesis of Phenanthridines
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Abstract
The palladium-catalyzed intramolecular C–H activation/C–C
cross-coupling has been developed for a straightforward and efficient
synthesis of phenanthridines. With Pd(OAc)<sub>2</sub> (4 mol %) as
the catalyst, PCy<sub>3</sub> (8 mol %) as the ligand, and Cs<sub>2</sub>CO<sub>3</sub> as the base, this protocol was applied to synthesize
a small library of phenanthridine derivatives in good yields in THF
